Neuromyelitis Optica: Review and utility of testing aquaporin-4 antibody in typical optic neuritis

Meagan Seay, Janet C. Rucker

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Neuromyelitis optica (NMO) is an autoimmune, inflammatory demyelinating disorder often leading to severe vision impairment and disability. The discovery of a diagnostic biomarker, the aquaporin-4 antibody (AQP4-IgG), transformed the clinical diagnosis and treatment of NMO and broadened the spectrum of disease [NMO spectrum disorders (NMOSD)]. Though the antibody is highly sensitive and specific to NMOSD, routine testing in patients with typical optic neuritis is considered controversial. This article will provide a brief review of NMOSD and highlight the pros and cons of routine testing in typical optic neuritis.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalAsia-Pacific Journal of Ophthalmology
Volume7
Issue number4
DOIs
StatePublished - 1 Jul 2018
Externally publishedYes

Keywords

  • Aquaporin-4 immunoglobulin
  • NMO
  • Optic neuritis

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