TY - JOUR
T1 - Neuromuscular ataxia
T2 - A new spontaneous mutation in the mouse
AU - Ward-Bailey, Patricia F.
AU - Wood, Bonnie
AU - Johnson, Kenneth R.
AU - Bronson, Rod T.
AU - Donahue, Leah Rae
AU - Davisson, Muriel T.
PY - 2000
Y1 - 2000
N2 - Neuromuscular ataxia, nma, is a new autosomal recessive mutation that arose spontaneously in CBA/J inbred mice at The Jackson Laboratory. The mutation, now maintained on the B6C3FeF1 hybrid background, when homozygous, causes small size, uncoordinated gait, dysmetria, dystonia, general weakness, and death shortly after weaning. No biochemical or morphological abnormalities have been detected. We used an intercross between the B6C3FeF1 mutant and CAST/Ei to map the nma mutation to the proximal end of Chr 12. The most likely gene order places the mutation between D12Mit270 and D12Mit54, non-recombinant with D12Mit2 in 96 tested meioses.
AB - Neuromuscular ataxia, nma, is a new autosomal recessive mutation that arose spontaneously in CBA/J inbred mice at The Jackson Laboratory. The mutation, now maintained on the B6C3FeF1 hybrid background, when homozygous, causes small size, uncoordinated gait, dysmetria, dystonia, general weakness, and death shortly after weaning. No biochemical or morphological abnormalities have been detected. We used an intercross between the B6C3FeF1 mutant and CAST/Ei to map the nma mutation to the proximal end of Chr 12. The most likely gene order places the mutation between D12Mit270 and D12Mit54, non-recombinant with D12Mit2 in 96 tested meioses.
UR - http://www.scopus.com/inward/record.url?scp=0033814295&partnerID=8YFLogxK
U2 - 10.1007/s003350010167
DO - 10.1007/s003350010167
M3 - Article
C2 - 11003693
AN - SCOPUS:0033814295
SN - 0938-8990
VL - 11
SP - 820
EP - 823
JO - Mammalian Genome
JF - Mammalian Genome
IS - 10
ER -