TY - JOUR
T1 - Neuroleptics in acute mania
T2 - Apharmacoepidemiologic study
AU - Chou, James C.Y.
AU - Zito, Julie Magno
AU - Vitrai, Jozsef
AU - Craig, Thomas J.
AU - Allingham, Baerbel H.
AU - Czobor, Pal
PY - 1996
Y1 - 1996
N2 - OBJECTIVE: To provide an epidemiologic descriptive analysis of the acute drug treatment of inpatients with bipolar mania in state psychiatric facilities in 1990. METHODS: We surveyed the first 3 weeks of drug treatment of all inpatients with bipolar mania who were admitted to 22 New York State adult psychiatric facilities during a 6-month period (n = 528). RESULTS: Almost all patients with mania were treated with neuroleptics. The mean ±SD neuroleptic dosage was 684 ±543 mg/d chlorpromazine equivalents. Sixty-one percent of the patients received lithium and 12% received carbamazepine or valproate. Neuroleptic dosage was related to age, with older patients receiving lower dosages. Patients receiving combination treatment of a neuroleptic with either lithium, an anticonvulsant, or a benzodiazepine received a mean neuroleptic dosage similar to that of patients treated with a neuroleptic alone. CONCLUSIONS: Although their use has been widely discouraged for mood disorders, neuroleptics have been the standard treatment for acute mania.
AB - OBJECTIVE: To provide an epidemiologic descriptive analysis of the acute drug treatment of inpatients with bipolar mania in state psychiatric facilities in 1990. METHODS: We surveyed the first 3 weeks of drug treatment of all inpatients with bipolar mania who were admitted to 22 New York State adult psychiatric facilities during a 6-month period (n = 528). RESULTS: Almost all patients with mania were treated with neuroleptics. The mean ±SD neuroleptic dosage was 684 ±543 mg/d chlorpromazine equivalents. Sixty-one percent of the patients received lithium and 12% received carbamazepine or valproate. Neuroleptic dosage was related to age, with older patients receiving lower dosages. Patients receiving combination treatment of a neuroleptic with either lithium, an anticonvulsant, or a benzodiazepine received a mean neuroleptic dosage similar to that of patients treated with a neuroleptic alone. CONCLUSIONS: Although their use has been widely discouraged for mood disorders, neuroleptics have been the standard treatment for acute mania.
UR - https://www.scopus.com/pages/publications/0030448815
U2 - 10.1177/106002809603001206
DO - 10.1177/106002809603001206
M3 - Article
C2 - 8968450
AN - SCOPUS:0030448815
SN - 1060-0280
VL - 30
SP - 1396
EP - 1398
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
IS - 12
ER -