Dopamine metabolism in human brain was studied by analysis of dopamine in discrete dopamine-rich regions of postmortem samples. The effect of postmortem delay on 3,4-dihydroxy-phenylacetic acid (DOPAC) was studied in the rat under similar conditions. DOPAC was found to be resistant to postmortem alterations under these conditions. Results of these studies support earlier CSF findings that homovanillic acid (HVA) is the major dopamine metabolite in human brain and that DOPAC is only a minor metabolic product.
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|Published - 1979