Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Christopher J. McDougle; Wayne K. Goodman; Lawrence H. Price; Pedro L. Delgado; John H. Krystal; Dennis S. Charney; George R. Heninger

doi:10.1176/ajp.147.5.652

Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Christopher J. McDougle
, Wayne K. Goodman
, Lawrence H. Price
, Pedro L. Delgado
, John H. Krystal
, Dennis S. Charney
, George R. Heninger

Research output: Contribution to journal › Article › peer-review

255 Scopus citations

Abstract

Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

Original language	English
Pages (from-to)	652-654
Number of pages	3
Journal	American Journal of Psychiatry
Volume	147
Issue number	5
DOIs	https://doi.org/10.1176/ajp.147.5.652
State	Published - 1990
Externally published	Yes

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title = "Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder",

abstract = "Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.",

author = "McDougle, \{Christopher J.\} and Goodman, \{Wayne K.\} and Price, \{Lawrence H.\} and Delgado, \{Pedro L.\} and Krystal, \{John H.\} and Charney, \{Dennis S.\} and Heninger, \{George R.\}",

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AU - McDougle, Christopher J.

AU - Goodman, Wayne K.

AU - Price, Lawrence H.

AU - Delgado, Pedro L.

AU - Krystal, John H.

AU - Charney, Dennis S.

AU - Heninger, George R.

PY - 1990

Y1 - 1990

N2 - Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

AB - Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

UR - https://www.scopus.com/pages/publications/0025326269

U2 - 10.1176/ajp.147.5.652

DO - 10.1176/ajp.147.5.652

M3 - Article

C2 - 1970224

AN - SCOPUS:0025326269

SN - 0002-953X

VL - 147

SP - 652

EP - 654

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 5

ER -

Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Abstract

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