Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

Madeline L. Pfau; Scott J. Russo

doi:10.1016/j.tins.2016.04.004

Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

Madeline L. Pfau, Scott J. Russo

Research output: Contribution to journal › Short survey › peer-review

42 Scopus citations

Abstract

Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.

Original language	English
Pages (from-to)	353-355
Number of pages	3
Journal	Trends in Neurosciences
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/j.tins.2016.04.004
State	Published - 1 Jun 2016

Keywords

Inflammation
Memory
Neurogenesis
Stress

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10.1016/j.tins.2016.04.004

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title = "Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice",

abstract = "Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.",

keywords = "Inflammation, Memory, Neurogenesis, Stress",

author = "Pfau, {Madeline L.} and Russo, {Scott J.}",

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year = "2016",

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T1 - Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

AU - Pfau, Madeline L.

AU - Russo, Scott J.

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N2 - Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.

AB - Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.

KW - Inflammation

KW - Memory

KW - Neurogenesis

KW - Stress

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U2 - 10.1016/j.tins.2016.04.004

DO - 10.1016/j.tins.2016.04.004

M3 - Short survey

C2 - 27130658

AN - SCOPUS:84964632161

SN - 0166-2236

VL - 39

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EP - 355

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 6

ER -

Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

Abstract

Keywords

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