TY - JOUR
T1 - Neuroimaging studies in post-traumatic stress disorder
AU - Grossman, Robert
AU - Buchsbaum, Monte S.
AU - Yehuda, Rachel
PY - 2002
Y1 - 2002
N2 - The authors review some of the advances that have been made in understanding the structural, biochemical, and functional neuroanatomy of post-traumatic stress disorder (PTSD). First, the authors review the primary brain regions that had been hypothesized a priori, from the phenomenology and neurobiology of PTSD, to be implicated in the pathophysiology. Next, they review findings from neuroimaging studies of these brain regions in PTSD and explain the various experimental methods and imaging technologies used in these studies. A broader perspective, including a discussion of additional brain areas that may be involved in PTSD, is synthesized. The authors conclude with a rationale and approach for studies testing sharply defined hypotheses and those using multidisciplinary strategies that integrate neuroimaging data with other cognitive, biologic, and genetic tools to study this complex disorder.
AB - The authors review some of the advances that have been made in understanding the structural, biochemical, and functional neuroanatomy of post-traumatic stress disorder (PTSD). First, the authors review the primary brain regions that had been hypothesized a priori, from the phenomenology and neurobiology of PTSD, to be implicated in the pathophysiology. Next, they review findings from neuroimaging studies of these brain regions in PTSD and explain the various experimental methods and imaging technologies used in these studies. A broader perspective, including a discussion of additional brain areas that may be involved in PTSD, is synthesized. The authors conclude with a rationale and approach for studies testing sharply defined hypotheses and those using multidisciplinary strategies that integrate neuroimaging data with other cognitive, biologic, and genetic tools to study this complex disorder.
UR - http://www.scopus.com/inward/record.url?scp=0036310968&partnerID=8YFLogxK
U2 - 10.1016/S0193-953X(01)00011-9
DO - 10.1016/S0193-953X(01)00011-9
M3 - Review article
C2 - 12136503
AN - SCOPUS:0036310968
SN - 0193-953X
VL - 25
SP - 317
EP - 340
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
IS - 2
ER -