Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

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Abstract

Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.

Original languageEnglish
Article number110988
JournalPsychiatry Research - Neuroimaging
Volume293
DOIs
StatePublished - 30 Nov 2019

Keywords

  • Cognitive remediation
  • Diffusion tensor imaging
  • Schizophrenia
  • Social skills training

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