Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

Margaret M. McClure; Fiona S. Graff; Joseph Triebwasser; M. Mercedes Perez-Rodriguez; Daniel R. Rosell; Philip R. Szeszko; King Wai Chu; Antonia S. New; Larry J. Siever; Erin A. Hazlett

doi:10.1016/j.pscychresns.2019.110988

Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

Margaret M. McClure, Fiona S. Graff, Joseph Triebwasser, M. Mercedes Perez-Rodriguez, Daniel R. Rosell, Philip R. Szeszko, King Wai Chu, Antonia S. New, Larry J. Siever, Erin A. Hazlett

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4 Scopus citations

Abstract

Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.

Original language	English
Article number	110988
Journal	Psychiatry Research - Neuroimaging
Volume	293
DOIs	https://doi.org/10.1016/j.pscychresns.2019.110988
State	Published - 30 Nov 2019

Keywords

Cognitive remediation
Diffusion tensor imaging
Schizophrenia
Social skills training

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McClure, M. M., Graff, F. S., Triebwasser, J., Perez-Rodriguez, M. M., Rosell, D. R., Szeszko, P. R., Chu, K. W., New, A. S., Siever, L. J., & Hazlett, E. A. (2019). Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia. Psychiatry Research - Neuroimaging, 293, [110988]. https://doi.org/10.1016/j.pscychresns.2019.110988

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title = "Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia",

abstract = "Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.",

keywords = "Cognitive remediation, Diffusion tensor imaging, Schizophrenia, Social skills training",

author = "McClure, {Margaret M.} and Graff, {Fiona S.} and Joseph Triebwasser and Perez-Rodriguez, {M. Mercedes} and Rosell, {Daniel R.} and Szeszko, {Philip R.} and Chu, {King Wai} and New, {Antonia S.} and Siever, {Larry J.} and Hazlett, {Erin A.}",

note = "Funding Information: This study was supported by VISN 2 MIRECC pilot grants to Dr. McClure, Dr. Triebwasser, and Dr. Graff, and a VA Merit Award to Dr. Hazlett (I01CX00026), the, VISN 2 Mental Illness Research, Education, and Clinical Center (MIRECC), and the VA Advanced Fellowship in Mental Health, VISN 2 MIRECC. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = nov,

day = "30",

doi = "10.1016/j.pscychresns.2019.110988",

language = "English",

volume = "293",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

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McClure, MM , Graff, FS, Triebwasser, J, Perez-Rodriguez, MM , Rosell, DR , Szeszko, PR, Chu, KW, New, AS, Siever, LJ & Hazlett, EA 2019, 'Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia', Psychiatry Research - Neuroimaging, vol. 293, 110988. https://doi.org/10.1016/j.pscychresns.2019.110988

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T2 - A pilot study in veterans with schizophrenia

AU - McClure, Margaret M.

AU - Graff, Fiona S.

AU - Triebwasser, Joseph

AU - Perez-Rodriguez, M. Mercedes

AU - Rosell, Daniel R.

AU - Szeszko, Philip R.

AU - Chu, King Wai

AU - New, Antonia S.

AU - Siever, Larry J.

AU - Hazlett, Erin A.

N1 - Funding Information: This study was supported by VISN 2 MIRECC pilot grants to Dr. McClure, Dr. Triebwasser, and Dr. Graff, and a VA Merit Award to Dr. Hazlett (I01CX00026), the, VISN 2 Mental Illness Research, Education, and Clinical Center (MIRECC), and the VA Advanced Fellowship in Mental Health, VISN 2 MIRECC. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/11/30

Y1 - 2019/11/30

N2 - Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.

AB - Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.

KW - Cognitive remediation

KW - Diffusion tensor imaging

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Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

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Keywords

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