TY - JOUR
T1 - Neuroimaging for drug addiction and related behaviors
AU - Parvaz, Muhammad A.
AU - Alia-Klein, Nelly
AU - Woicik, Patricia A.
AU - Volkow, Nora D.
AU - Goldstein, Rita Z.
N1 - Funding Information:
This work was supported by grants from the National Institute on Drug Abuse [1R01DA023579 to R.Z.G.] and General Clinical Research Center [5-MO1-RR-10710].
Funding Information:
This manuscript has been authored by Brookhaven Science Associates, LLC under Contract No. DE-AC02-98CHI-886 with the USA Department of Energy. The United States Government retains, and the publisher, by accepting the article for publication, acknowledges, a world-wide license to publish or reproduce the published form of this article, or allow others to do so, for the United States Government purposes.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.
AB - In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.
KW - Dopamine
KW - Electroencephalography (EEG)
KW - Event-related potentials (ERPs)
KW - Magnetic resonance imaging (MRI)
KW - Positron emission tomography (PET)
KW - Prefrontal cortex
UR - https://www.scopus.com/pages/publications/83655181381
U2 - 10.1515/RNS.2011.055
DO - 10.1515/RNS.2011.055
M3 - Article
C2 - 22117165
AN - SCOPUS:83655181381
SN - 0334-1763
VL - 22
SP - 609
EP - 624
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 6
ER -