Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders

Florence F. Roussotte, Madelaine Daianu, Neda Jahanshad, Cassandra D. Leonardo, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Neuroimaging offers a powerful means to assess the trajectory of brain degeneration in a variety of disorders, including Alzheimer's disease (AD). Here we describe how multi-modal imaging can be used to study the changing brain during the different stages of AD. We integrate findings from a range of studies using magnetic resonance imaging (MRI), positron emission tomography (PET), functional MRI (fMRI) and diffusion weighted imaging (DWI). Neuroimaging reveals how risk genes for degenerative disorders affect the brain, including several recently discovered genetic variants that may disrupt brain connectivity. We review some recent neuroimaging studies of genetic polymorphisms associated with increased risk for late-onset Alzheimer's disease (LOAD). Some genetic variants that increase risk for drug addiction may overlap with those associated with degenerative brain disorders. These common associations offer new insight into mechanisms underlying neurodegeneration and addictive behaviors, and may offer new leads for treating them before severe and irreversible neurological symptoms appear.

Original languageEnglish
Pages (from-to)217-233
Number of pages17
JournalBrain Imaging and Behavior
Volume8
Issue number2
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Addiction
  • Alzheimer's disease
  • Imaging genetics
  • Multi-modal imaging
  • Neurodegeneration

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