TY - JOUR
T1 - Neurohormonal signaling pathways and the regulation of Alzheimer β- amyloid precursor metabolism
AU - Gandy, Sam
N1 - Funding Information:
This work was supported by the USPHS, the New York State Office of Mental Health, and the Research Foundation for Mental Hygiene. The author receives or has received honoraria and/or extramural support from the Women’s Health Research Institute of Wyeth-Ayerst Pharmaceuticals (a division of American Home Corporation), Warner Lambert/Parke-Davis Pharmaceuticals, Hoffman La Roche Pharmaceuticals and Neurogen Corporation.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half. Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.
AB - Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half. Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.
UR - http://www.scopus.com/inward/record.url?scp=0032796128&partnerID=8YFLogxK
U2 - 10.1016/S1043-2760(99)00166-6
DO - 10.1016/S1043-2760(99)00166-6
M3 - Review article
AN - SCOPUS:0032796128
SN - 1043-2760
VL - 10
SP - 273
EP - 279
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 7
ER -