Neuroendocrine neoplasms of the sinonasal region

Diana Bell; Ehab Y. Hanna; Randal S. Weber; Franco Demonte; Asterios Triantafyllou; James S. Lewis; Antonio Cardesa; Pieter J. Slootweg; Göran Stenman; Douglas R. Gnepp; Kenneth O. Devaney; Juan P. Rodrigo; Alessandra Rinaldo; Bruce M. Wenig; William H. Westra; Justin A. Bishop; Henrik Hellquist; Jennifer L. Hunt; Kimihide Kusafuka; Bayardo Perez-Ordoñez; Michelle D. Williams; Robert P. Takes; Alfio Ferlito

doi:10.1002/hed.24152

Neuroendocrine neoplasms of the sinonasal region

Diana Bell, Ehab Y. Hanna, Randal S. Weber, Franco Demonte, Asterios Triantafyllou, James S. Lewis, Antonio Cardesa, Pieter J. Slootweg, Göran Stenman, Douglas R. Gnepp, Kenneth O. Devaney, Juan P. Rodrigo, Alessandra Rinaldo, Bruce M. Wenig, William H. Westra, Justin A. Bishop, Henrik Hellquist, Jennifer L. Hunt, Kimihide Kusafuka, Bayardo Perez-OrdoñezMichelle D. Williams, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.

Original language	English
Pages (from-to)	E2259-E2266
Journal	Head and Neck
Volume	38
DOIs	https://doi.org/10.1002/hed.24152
State	Published - 1 Apr 2016
Externally published	Yes

Keywords

immunohistochemistry
neuroendocrine neoplasms
olfactory neuroblastoma
sinonasal carcinoma
sinonasal undifferentiated carcinoma

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10.1002/hed.24152

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Bell, D., Hanna, E. Y., Weber, R. S., Demonte, F., Triantafyllou, A., Lewis, J. S., Cardesa, A., Slootweg, P. J., Stenman, G., Gnepp, D. R., Devaney, K. O., Rodrigo, J. P., Rinaldo, A., Wenig, B. M., Westra, W. H., Bishop, J. A., Hellquist, H., Hunt, J. L., Kusafuka, K., ... Ferlito, A. (2016). Neuroendocrine neoplasms of the sinonasal region. Head and Neck, 38, E2259-E2266. https://doi.org/10.1002/hed.24152

@article{7c3e466f13fd49d68eafc3b56f8e59e0,

title = "Neuroendocrine neoplasms of the sinonasal region",

abstract = "Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.",

keywords = "immunohistochemistry, neuroendocrine neoplasms, olfactory neuroblastoma, sinonasal carcinoma, sinonasal undifferentiated carcinoma",

author = "Diana Bell and Hanna, {Ehab Y.} and Weber, {Randal S.} and Franco Demonte and Asterios Triantafyllou and Lewis, {James S.} and Antonio Cardesa and Slootweg, {Pieter J.} and G{\"o}ran Stenman and Gnepp, {Douglas R.} and Devaney, {Kenneth O.} and Rodrigo, {Juan P.} and Alessandra Rinaldo and Wenig, {Bruce M.} and Westra, {William H.} and Bishop, {Justin A.} and Henrik Hellquist and Hunt, {Jennifer L.} and Kimihide Kusafuka and Bayardo Perez-Ordo{\~n}ez and Williams, {Michelle D.} and Takes, {Robert P.} and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc..",

year = "2016",

month = apr,

day = "1",

doi = "10.1002/hed.24152",

language = "English",

volume = "38",

pages = "E2259--E2266",

journal = "Head and Neck",

issn = "1043-3074",

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Bell, D, Hanna, EY, Weber, RS, Demonte, F, Triantafyllou, A, Lewis, JS, Cardesa, A, Slootweg, PJ, Stenman, G, Gnepp, DR, Devaney, KO, Rodrigo, JP, Rinaldo, A, Wenig, BM, Westra, WH, Bishop, JA, Hellquist, H, Hunt, JL, Kusafuka, K, Perez-Ordoñez, B, Williams, MD, Takes, RP & Ferlito, A 2016, 'Neuroendocrine neoplasms of the sinonasal region', Head and Neck, vol. 38, pp. E2259-E2266. https://doi.org/10.1002/hed.24152

TY - JOUR

T1 - Neuroendocrine neoplasms of the sinonasal region

AU - Bell, Diana

AU - Hanna, Ehab Y.

AU - Weber, Randal S.

AU - Demonte, Franco

AU - Triantafyllou, Asterios

AU - Lewis, James S.

AU - Cardesa, Antonio

AU - Slootweg, Pieter J.

AU - Stenman, Göran

AU - Gnepp, Douglas R.

AU - Devaney, Kenneth O.

AU - Rodrigo, Juan P.

AU - Rinaldo, Alessandra

AU - Wenig, Bruce M.

AU - Westra, William H.

AU - Bishop, Justin A.

AU - Hellquist, Henrik

AU - Hunt, Jennifer L.

AU - Kusafuka, Kimihide

AU - Perez-Ordoñez, Bayardo

AU - Williams, Michelle D.

AU - Takes, Robert P.

AU - Ferlito, Alfio

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.

AB - Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.

KW - immunohistochemistry

KW - neuroendocrine neoplasms

KW - olfactory neuroblastoma

KW - sinonasal carcinoma

KW - sinonasal undifferentiated carcinoma

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DO - 10.1002/hed.24152

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C2 - 26041714

AN - SCOPUS:84937160647

SN - 1043-3074

VL - 38

SP - E2259-E2266

JO - Head and Neck

JF - Head and Neck

ER -

Neuroendocrine neoplasms of the sinonasal region

Abstract

Keywords

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