Neuroendocrine aspects of PTSD

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations


This chapter discussed how neuroendocrine findings in posttraumatic stress disorder (PTSD) potentially inform hypothalamic-pituitary-adrenal (HPA) alterations in PTSD and highlight alterations relevant to the identification of targets for drug development. Most studies demonstrate alterations consistent with an enhanced negative feedback inhibition of cortisol on the pituitary, an overall hyperreactivity of other target tissues (adrenal gland, hypothalamus), or both in PTSD. However, findings of low cortisol and increased reactivity of the pituitary in PTSD are also consistent with reduced adrenal output. The observations in PTSD are part of a growing body of neuroendocrine data providing evidence of insufficient glucocorticoid signaling in stress-related neuropsychiatric disorders.

Original languageEnglish
Title of host publicationAnxiety and Anxiolytic Drugs
PublisherSpringer Science and Business Media, LLC
Number of pages33
ISBN (Print)9783540225683
StatePublished - 2005

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • CRF
  • Cortisol
  • Glucocorticoid receptors
  • Negative feedback inhibition
  • Neuroendocrine alterations
  • Posttraumatic stress disorder


Dive into the research topics of 'Neuroendocrine aspects of PTSD'. Together they form a unique fingerprint.

Cite this