TY - JOUR
T1 - Neurodevelopmental control by thyroid hormone receptors
AU - Forrest, Douglas
AU - Reh, Thomas A.
AU - Rüsch, Alfons
N1 - Funding Information:
Work in the authors’ laboratories is supported by March of Dimes Birth Defects Foundation, the Hirschl Trust, the National Institutes of Health, the National Science Foundation and the German Research Council. We thank many colleagues for useful discussions of the topics in this review, V Galton and I Jones for comments on the manuscript, and B Vennström, M Kelley, G Richardson, J Samarut, F Flamant, E Gurnell and K Chatterjee for discussing unpublished results.
PY - 2002/2/1
Y1 - 2002/2/1
N2 - Recent studies have provided insights into the neurodevelopmental functions of thyroid hormone signaling. The nuclear thyroid hormone receptors (TRs) are ligand-activated transcription factors and a variety of TR isotypes, generated by two genes, mediate distinct processes. In addition, deiodinase enzymes that regulate levels of the main active form of thyroid hormone, T3, are likely to cooperate closely with TRs in specifying a localized and timely response to thyroid hormones in target tissues. Some of the most sensitive processes controlled by these pathways are in the auditory and visual sensory systems.
AB - Recent studies have provided insights into the neurodevelopmental functions of thyroid hormone signaling. The nuclear thyroid hormone receptors (TRs) are ligand-activated transcription factors and a variety of TR isotypes, generated by two genes, mediate distinct processes. In addition, deiodinase enzymes that regulate levels of the main active form of thyroid hormone, T3, are likely to cooperate closely with TRs in specifying a localized and timely response to thyroid hormones in target tissues. Some of the most sensitive processes controlled by these pathways are in the auditory and visual sensory systems.
UR - http://www.scopus.com/inward/record.url?scp=0036472340&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(02)00289-1
DO - 10.1016/S0959-4388(02)00289-1
M3 - Review article
C2 - 11861164
AN - SCOPUS:0036472340
SN - 0959-4388
VL - 12
SP - 49
EP - 56
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -