Neurod1 is essential for the survival and maturation of adult-born neurons

Zhengliang Gao; Kerstin Ure; Jessica L. Ables; Diane C. Lagace; Klaus Armin Nave; Sandra Goebbels; Amelia J. Eisch; Jenny Hsieh

doi:10.1038/nn.2385

Neurod1 is essential for the survival and maturation of adult-born neurons

Zhengliang Gao
, Kerstin Ure
, Jessica L. Ables
, Diane C. Lagace
, Klaus Armin Nave
, Sandra Goebbels
, Amelia J. Eisch
, Jenny Hsieh

Research output: Contribution to journal › Article › peer-review

390 Scopus citations

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

Original language	English
Pages (from-to)	1090-1092
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/nn.2385
State	Published - Sep 2009
Externally published	Yes

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@article{d3744ecaa14c4ee2851d1a7af5a2b1b2,

title = "Neurod1 is essential for the survival and maturation of adult-born neurons",

abstract = "The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.",

author = "Zhengliang Gao and Kerstin Ure and Ables, \{Jessica L.\} and Lagace, \{Diane C.\} and Nave, \{Klaus Armin\} and Sandra Goebbels and Eisch, \{Amelia J.\} and Jenny Hsieh",

note = "Funding Information: We thank L. Zhang, J. Ma and Y. Jiang for technical assistance and S. Goetsch for artwork. We also thank J. Johnson, C.-L. Zhang and J. Schneider for helpful comments on the manuscript. This work was supported in part by the Epilepsy Foundation (Z.G.), a US National Institutes of Health training grant (K.U.), the Texas Advanced Research Program (grant numbers 3594-0029-2007 and 10019-0013-2006), the Ellison Medical Foundation (grant number AG-NS-0371-06) and the Welch Foundation (grant number I-1660, J.H.).",

year = "2009",

month = sep,

doi = "10.1038/nn.2385",

language = "English",

volume = "12",

pages = "1090--1092",

journal = "Nature Neuroscience",

issn = "1097-6256",

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T1 - Neurod1 is essential for the survival and maturation of adult-born neurons

AU - Gao, Zhengliang

AU - Ure, Kerstin

AU - Ables, Jessica L.

AU - Lagace, Diane C.

AU - Nave, Klaus Armin

AU - Goebbels, Sandra

AU - Eisch, Amelia J.

AU - Hsieh, Jenny

N1 - Funding Information: We thank L. Zhang, J. Ma and Y. Jiang for technical assistance and S. Goetsch for artwork. We also thank J. Johnson, C.-L. Zhang and J. Schneider for helpful comments on the manuscript. This work was supported in part by the Epilepsy Foundation (Z.G.), a US National Institutes of Health training grant (K.U.), the Texas Advanced Research Program (grant numbers 3594-0029-2007 and 10019-0013-2006), the Ellison Medical Foundation (grant number AG-NS-0371-06) and the Welch Foundation (grant number I-1660, J.H.).

PY - 2009/9

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N2 - The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

AB - The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

UR - https://www.scopus.com/pages/publications/69449107409

U2 - 10.1038/nn.2385

DO - 10.1038/nn.2385

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AN - SCOPUS:69449107409

SN - 1097-6256

VL - 12

SP - 1090

EP - 1092

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 9

ER -

Neurod1 is essential for the survival and maturation of adult-born neurons

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