Neurobiology with caged calcium

Graham C.R. Ellis-Davies

doi:10.1021/cr078210i

Neurobiology with caged calcium

Graham C.R. Ellis-Davies

Research output: Contribution to journal › Review article › peer-review

129 Scopus citations

Abstract

A review on the wide variety of cells and cellular functions regulated by ionized calcium (Ca²⁺) is given as well as the history of the development of caged Ca²⁺ molecules referring to the requirements of the experimental application of each photosensitive probe. The term "caged" is defined to be the functional encapsulation of a chemical messenger in a biologically inert and photosensitive form. Specific topics include: on what does Ca²⁺ inside cells; the key biological applications of caged Ca²⁺; and finally, the two-photon uncaging of Ca²⁺ in living cells.

Original language	English
Pages (from-to)	1603-1613
Number of pages	11
Journal	Chemical Reviews
Volume	108
Issue number	5
DOIs	https://doi.org/10.1021/cr078210i
State	Published - May 2008
Externally published	Yes

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title = "Neurobiology with caged calcium",

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AB - A review on the wide variety of cells and cellular functions regulated by ionized calcium (Ca2+) is given as well as the history of the development of caged Ca2+ molecules referring to the requirements of the experimental application of each photosensitive probe. The term "caged" is defined to be the functional encapsulation of a chemical messenger in a biologically inert and photosensitive form. Specific topics include: on what does Ca2+ inside cells; the key biological applications of caged Ca2+; and finally, the two-photon uncaging of Ca2+ in living cells.

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Neurobiology with caged calcium

Abstract

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