@article{70f02db4eff342c39aa822517d518834,
title = "Neurobiology of Resilience: Interface Between Mind and Body",
abstract = "Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.",
keywords = "Blood-brain barrier, Gut microbiota, Inflammation, Major depressive disorder, Mesolimbic reward circuit, Posttraumatic stress disorder, Resilience, Stress",
author = "Flurin Cathomas and Murrough, {James W.} and Nestler, {Eric J.} and Han, {Ming Hu} and Russo, {Scott J.}",
note = "Funding Information: This work was supported by National Institute of Mental Health Grant Nos. R01 MH090264 , P50 MH096890 , and R01 MH104559 (to SJR), R56 MH115409 (to M-HH), and P50 MH096890 (to EJN), National Center for Complementary and Integrative Health Grant No. P50 AT008661-01 (to SJR), and an Early Postdoc Mobility Fellowship of the Swiss National Science Foundation and a Walter and Gertrud Siegenthaler Postdoctoral Fellowship (to FC). Funding Information: This work was supported by National Institute of Mental Health Grant Nos. R01 MH090264, P50 MH096890, and R01 MH104559 (to SJR), R56 MH115409 (to M-HH), and P50 MH096890 (to EJN), National Center for Complementary and Integrative Health Grant No. P50 AT008661-01 (to SJR), and an Early Postdoc Mobility Fellowship of the Swiss National Science Foundation and a Walter and Gertrud Siegenthaler Postdoctoral Fellowship (to FC). SJR has provided consultation services to Danone and Sunovion Pharmaceuticals and has received research support from Janssen Pharmaceuticals. JWM has provided consultation services to Boehreinger Ingelheim, Sage Therapeutics, Novartis, Allergan, Fortress Biotech, Janssen Research and Development, Medavante-Prophase, and Global Medical Education and has received research support from Avanir Pharmaceuticals, Inc. JWM is named on a patent pending for neuropeptide Y as a treatment for mood and anxiety disorders. EJN has provided consultation services to PsychoGenics, Merck, and Janssen and is a Director of Berg. The other authors report no biomedical financial interests or potential conflicts of interest. Publisher Copyright: {\textcopyright} 2019 Society of Biological Psychiatry",
year = "2019",
month = sep,
day = "15",
doi = "10.1016/j.biopsych.2019.04.011",
language = "English",
volume = "86",
pages = "410--420",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "6",
}