Neurobiological factors underlying psychosocial moderators of childhood stress and trauma

Fatih Ozbay, Vansh Sharma, Joan Kaufman, Bruce McEwen, Dennis Charney, Steven Southwick

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


This chapter discusses resilience as a psychological construct, and describes some of the neurobiological and psychosocial features that are believed to characterize stress-resilient individuals. It reviews the current understanding regarding the neurobiology of stress resilience, including neurocircuitry, neurochemistry and the role of gene-environment interactions. The chapter deals with a consideration of information-processing theory and a discussion of the neurobiological basis of social support in the development of stress resilience. The neurocircuitry of stress resilience consists of a variety of brain structures intimately involved in mediating the stress response, including the amygdala, hypothalamus, hippocampus and prefrontal cortex. Gene-environment interactions, as typified by the diathesis-stress model of illness, are important factors in the development of stress resilience. Different forms of social support have been shown to play a role in the development of stress resilience and in reversing stress-related adverse changes.

Original languageEnglish
Title of host publicationThe Impact of Early Life Trauma on Health and Disease
Subtitle of host publicationThe Hidden Epidemic
PublisherCambridge University Press
Number of pages11
ISBN (Electronic)9780511777042
ISBN (Print)9780521880268
StatePublished - 1 Jan 2010


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