Neurobiological aspects of PTSD: Review of clinical and preclinical studies

John H. Krystal; Thomas R. Kosten; Steven Southwick; John W. Mason; Bruce D. Perry; Earl L. Giller

doi:10.1016/S0005-7894(89)80068-1

Neurobiological aspects of PTSD: Review of clinical and preclinical studies

John H. Krystal
, Thomas R. Kosten
, Steven Southwick
, John W. Mason
, Bruce D. Perry
, Earl L. Giller

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Although physiologic studies of post-traumatic stress disorder (PTSD) date to World War I, clinical neuroscience has only recently explored biological mechanisms involved in this disorder. This review will selectively consider clinical and preclinical studies pertaining to biological theories and pharmacological treatments for PTSD, highlighting the role of central noradrenergic systems in its pathophysiology.

Original language	English
Pages (from-to)	177-198
Number of pages	22
Journal	Behavior Therapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/S0005-7894(89)80068-1
State	Published - 1989
Externally published	Yes

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title = "Neurobiological aspects of PTSD: Review of clinical and preclinical studies",

abstract = "Although physiologic studies of post-traumatic stress disorder (PTSD) date to World War I, clinical neuroscience has only recently explored biological mechanisms involved in this disorder. This review will selectively consider clinical and preclinical studies pertaining to biological theories and pharmacological treatments for PTSD, highlighting the role of central noradrenergic systems in its pathophysiology.",

author = "Krystal, \{John H.\} and Kosten, \{Thomas R.\} and Steven Southwick and Mason, \{John W.\} and Perry, \{Bruce D.\} and Giller, \{Earl L.\}",

year = "1989",

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T2 - Review of clinical and preclinical studies

AU - Krystal, John H.

AU - Kosten, Thomas R.

AU - Southwick, Steven

AU - Mason, John W.

AU - Perry, Bruce D.

AU - Giller, Earl L.

PY - 1989

Y1 - 1989

N2 - Although physiologic studies of post-traumatic stress disorder (PTSD) date to World War I, clinical neuroscience has only recently explored biological mechanisms involved in this disorder. This review will selectively consider clinical and preclinical studies pertaining to biological theories and pharmacological treatments for PTSD, highlighting the role of central noradrenergic systems in its pathophysiology.

AB - Although physiologic studies of post-traumatic stress disorder (PTSD) date to World War I, clinical neuroscience has only recently explored biological mechanisms involved in this disorder. This review will selectively consider clinical and preclinical studies pertaining to biological theories and pharmacological treatments for PTSD, highlighting the role of central noradrenergic systems in its pathophysiology.

UR - https://www.scopus.com/pages/publications/0024332285

U2 - 10.1016/S0005-7894(89)80068-1

DO - 10.1016/S0005-7894(89)80068-1

M3 - Review article

AN - SCOPUS:0024332285

SN - 0005-7894

VL - 20

SP - 177

EP - 198

JO - Behavior Therapy

JF - Behavior Therapy

IS - 2

ER -

Neurobiological aspects of PTSD: Review of clinical and preclinical studies

Abstract

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