Neural stem and progenitor cells in health and disease

Ian Ladran; Ngoc Tran; Aaron Topol; Kristen J. Brennand

doi:10.1002/wsbm.1239

Neural stem and progenitor cells in health and disease

Ian Ladran, Ngoc Tran, Aaron Topol, Kristen J. Brennand

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs, the regulation of NSPC fate and function, in the context of cell-based disease models and patient-specific cell-replacement therapies, warrants review.

Original language	English
Pages (from-to)	701-715
Number of pages	15
Journal	Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/wsbm.1239
State	Published - Nov 2013

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10.1002/wsbm.1239

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title = "Neural stem and progenitor cells in health and disease",

abstract = "Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs, the regulation of NSPC fate and function, in the context of cell-based disease models and patient-specific cell-replacement therapies, warrants review.",

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AU - Tran, Ngoc

AU - Topol, Aaron

AU - Brennand, Kristen J.

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AB - Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs, the regulation of NSPC fate and function, in the context of cell-based disease models and patient-specific cell-replacement therapies, warrants review.

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Neural stem and progenitor cells in health and disease

Abstract

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