Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease

S. F. Kazim, K. Iqbal

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder, which contributes significantly to the health care burden particularly in the developed world. As yet, there is no effective treatment for AD. Besides the presence of amyloid ? plaques and neurofibrillary tangles, AD is characterized by neurogenic and synaptic failure leading to cognitive decline. Neural regeneration-based strategy represents a highly promising therapeutic approach for AD. Shifting the balance from neurodegeneration to neural regeneration with neurotrophic small-molecule peptide mimetics has shown promise in the animal models of AD. Our work with a ciliary neurotrophic factor-based neurogenic and neurotrophic peptidergic compound has shown that neural regeneration-based therapeutic approach can be disease modifying for AD. Human clinical trials are warranted to validate the efficacy of neural regeneration-based approach for AD.

Original languageEnglish
Title of host publicationNeuroprotection in Alzheimer's Disease
PublisherElsevier Inc.
Pages3-29
Number of pages27
ISBN (Electronic)9780128037126
ISBN (Print)9780128036907
DOIs
StatePublished - 20 Jan 2017
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid
  • Brain-derived neurotrophic factor (BDNF)
  • Ciliary neurotrophic factor (CNTF)
  • Cognition
  • Neural regeneration
  • Neurodegeneration
  • Neurogenesis
  • Neuronal and synaptic plasticity
  • Tau hyperphosphorylation

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