TY - JOUR
T1 - Neural correlates of interoception
T2 - Effects of interoceptive focus and relationship to dimensional measures of body awareness
AU - Stern, Emily R.
AU - Grimaldi, Stephanie J.
AU - Muratore, Alexandra
AU - Murrough, James
AU - Leibu, Evan
AU - Fleysher, Lazar
AU - Goodman, Wayne K.
AU - Burdick, Katherine E.
N1 - Funding Information:
Additional Supporting Information may be found in the online version of this article. Contract grant sponsor: National Institute of Mental Health; Contract grant numbers: R21MH107589, R01MH111794 *Correspondence to: Emily R. Stern; Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Interoception has been defined as the sensing of the physiological condition of the body, with interoceptive sensibility (IS) characterizing an individual's self-reported awareness of internal sensation. IS is a multidimensional construct including not only the tendency to be aware of sensation but also how sensations are interpreted, regulated, and used to inform behavior, with different dimensions relating to different aspects of health and disease. Here we investigated neural mechanisms of interoception when healthy individuals attended to their heartbeat and skin temperature, and examined the relationship between neural activity during interoception and individual differences in self-reported IS using the Multidimensional Scale of Interoceptive Awareness (MAIA). Consistent with prior work, interoception activated a network involving insula and sensorimotor regions but also including occipital, temporal, and prefrontal cortex. Differences based on interoceptive focus (heartbeat vs skin temperature) were found in insula, sensorimotor regions, occipital cortex, and limbic areas. Factor analysis of MAIA dimensions revealed 3 dissociable components of IS in our dataset, only one of which was related to neural activity during interoception. Reduced scores on the third factor, which reflected reduced ability to control attention to body sensation and increased tendency to distract from and worry about aversive sensations, was associated with greater activation in many of the same regions as those involved in interoception, including insula, sensorimotor, anterior cingulate, and temporal cortex. These data suggest that self-rated interoceptive sensibility is related to altered activation in regions involved in monitoring body state, which has implications for disorders associated with abnormality of interoception. Hum Brain Mapp 38:6068–6082, 2017.
AB - Interoception has been defined as the sensing of the physiological condition of the body, with interoceptive sensibility (IS) characterizing an individual's self-reported awareness of internal sensation. IS is a multidimensional construct including not only the tendency to be aware of sensation but also how sensations are interpreted, regulated, and used to inform behavior, with different dimensions relating to different aspects of health and disease. Here we investigated neural mechanisms of interoception when healthy individuals attended to their heartbeat and skin temperature, and examined the relationship between neural activity during interoception and individual differences in self-reported IS using the Multidimensional Scale of Interoceptive Awareness (MAIA). Consistent with prior work, interoception activated a network involving insula and sensorimotor regions but also including occipital, temporal, and prefrontal cortex. Differences based on interoceptive focus (heartbeat vs skin temperature) were found in insula, sensorimotor regions, occipital cortex, and limbic areas. Factor analysis of MAIA dimensions revealed 3 dissociable components of IS in our dataset, only one of which was related to neural activity during interoception. Reduced scores on the third factor, which reflected reduced ability to control attention to body sensation and increased tendency to distract from and worry about aversive sensations, was associated with greater activation in many of the same regions as those involved in interoception, including insula, sensorimotor, anterior cingulate, and temporal cortex. These data suggest that self-rated interoceptive sensibility is related to altered activation in regions involved in monitoring body state, which has implications for disorders associated with abnormality of interoception. Hum Brain Mapp 38:6068–6082, 2017.
KW - body sensation
KW - fMRI
KW - individual differences
KW - insula
KW - interoception
KW - somatosensory
UR - http://www.scopus.com/inward/record.url?scp=85029356389&partnerID=8YFLogxK
U2 - 10.1002/hbm.23811
DO - 10.1002/hbm.23811
M3 - Article
C2 - 28901713
AN - SCOPUS:85029356389
SN - 1065-9471
VL - 38
SP - 6068
EP - 6082
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 12
ER -