Neural contribution to the effect of glucagon-like peptide-1-(7 - 36) amide on arterial blood pressure in rats

José Manuel Barragán, John Eng, Raquel Rodríguez, Enrique Blázquez

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

This study was designed to determine the contribution of the central nervous system (CNS) to the effects of glucagon-like peptide-1-(7 - 36) amide (tGLP-1) on arterial blood pressure and heart rate in rats. Accordingly, intracerebroventricular administration of the peptide produced an increase in cardiovascular parameters, which was blocked by previous administration of exendin-(9 39) through the same route, but not when it was intravenously injected. Intravenous administration of TGLP-1 produced a significant increase in arterial blood pressure and heart rate, which was blocked by the previous intracerebroventricular or intravenous administration of exendin- (9 - 39). Bilateral vagotomy blocked the stimulating effect of intracerebroventricular tGLP-1 administration on arterial blood pressure and heart rate. Also, bilateral vagotomy prevented the blocking effect of intracerebroventricular but not of intravenous exendin-(9 - 39) on cardiovascular parameters after intravenous administration of tGLP-1. These findings suggest that the action of tGLP-1 on cardiovascular parameters is under a dual control generated in the CNS and in peripheral structures and that the neural information emerging in the brain is transmitted to the periphery through the vagus nerve.

Original languageEnglish
Pages (from-to)E784-E791
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume277
Issue number5 40-5
DOIs
StatePublished - Nov 1999
Externally publishedYes

Keywords

  • Cardiovascular parameters
  • Neural control
  • Vagal mediation

Fingerprint

Dive into the research topics of 'Neural contribution to the effect of glucagon-like peptide-1-(7 - 36) amide on arterial blood pressure in rats'. Together they form a unique fingerprint.

Cite this