NetworkPainter: Dynamic intracellular pathway animation in Cytobank

Jonathan R. Karr; Harendra Guturu; Edward Y. Chen; Stuart L. Blair; Jonathan M. Irish; Nikesh Kotecha; Markus W. Covert

doi:10.1186/s12859-015-0602-4

NetworkPainter: Dynamic intracellular pathway animation in Cytobank

Jonathan R. Karr, Harendra Guturu, Edward Y. Chen, Stuart L. Blair, Jonathan M. Irish, Nikesh Kotecha, Markus W. Covert

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. Results: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and "paint" pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. Conclusion: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data.

Original language	English
Article number	172
Journal	BMC Bioinformatics
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12859-015-0602-4
State	Published - 25 May 2015

Keywords

Animation
Cytometry
Network
Systems biology
Visualization

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title = "NetworkPainter: Dynamic intracellular pathway animation in Cytobank",

abstract = "Background: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. Results: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and {"}paint{"} pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. Conclusion: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data.",

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T2 - Dynamic intracellular pathway animation in Cytobank

AU - Karr, Jonathan R.

AU - Guturu, Harendra

AU - Chen, Edward Y.

AU - Blair, Stuart L.

AU - Irish, Jonathan M.

AU - Kotecha, Nikesh

AU - Covert, Markus W.

PY - 2015/5/25

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AB - Background: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. Results: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and "paint" pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. Conclusion: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data.

KW - Animation

KW - Cytometry

KW - Network

KW - Systems biology

KW - Visualization

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NetworkPainter: Dynamic intracellular pathway animation in Cytobank

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Keywords

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