Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo; Catalina Salinas Cevallos; Krystina Woods; Vicente Maco Flores; Gweneth Francis; David C. Perlman; Manuel Revuelta; Donna Mildvan; Mary Waldron; Tessa Gomez; Sanjana Koshy; Tomasz Jodlowski; William Riley; Jörg J. Ruhe

doi:10.1128/AAC.00827-13

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo
, Catalina Salinas Cevallos
, Krystina Woods
, Vicente Maco Flores
, Gweneth Francis
, David C. Perlman
, Manuel Revuelta
, Donna Mildvan
, Mary Waldron
, Tessa Gomez
, Sanjana Koshy
, Tomasz Jodlowski
, William Riley
, Jörg J. Ruhe

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.

Original language	English
Pages (from-to)	5743-5746
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00827-13
State	Published - Nov 2013
Externally published	Yes

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10.1128/AAC.00827-13

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Nigo, M., Cevallos, C. S., Woods, K., Flores, V. M., Francis, G., Perlman, D. C., Revuelta, M., Mildvan, D., Waldron, M., Gomez, T., Koshy, S., Jodlowski, T., Riley, W., & Ruhe, J. J. (2013). Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 57(11), 5743-5746. https://doi.org/10.1128/AAC.00827-13

@article{7cec3e73ef4d4323aaa0cbc77a360cfc,

title = "Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae",

abstract = "We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9\%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95\% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.",

author = "Masayuki Nigo and Cevallos, \{Catalina Salinas\} and Krystina Woods and Flores, \{Vicente Maco\} and Gweneth Francis and Perlman, \{David C.\} and Manuel Revuelta and Donna Mildvan and Mary Waldron and Tessa Gomez and Sanjana Koshy and Tomasz Jodlowski and William Riley and Ruhe, \{J{\"o}rg J.\}",

year = "2013",

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doi = "10.1128/AAC.00827-13",

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Nigo, M, Cevallos, CS, Woods, K, Flores, VM, Francis, G, Perlman, DC, Revuelta, M, Mildvan, D, Waldron, M, Gomez, T , Koshy, S, Jodlowski, T, Riley, W & Ruhe, JJ 2013, 'Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae', Antimicrobial Agents and Chemotherapy, vol. 57, no. 11, pp. 5743-5746. https://doi.org/10.1128/AAC.00827-13

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T1 - Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

AU - Nigo, Masayuki

AU - Cevallos, Catalina Salinas

AU - Woods, Krystina

AU - Flores, Vicente Maco

AU - Francis, Gweneth

AU - Perlman, David C.

AU - Revuelta, Manuel

AU - Mildvan, Donna

AU - Waldron, Mary

AU - Gomez, Tessa

AU - Koshy, Sanjana

AU - Jodlowski, Tomasz

AU - Riley, William

AU - Ruhe, Jörg J.

PY - 2013/11

Y1 - 2013/11

N2 - We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.

AB - We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.

UR - https://www.scopus.com/pages/publications/84885926558

U2 - 10.1128/AAC.00827-13

DO - 10.1128/AAC.00827-13

M3 - Article

C2 - 23979745

AN - SCOPUS:84885926558

SN - 0066-4804

VL - 57

SP - 5743

EP - 5746

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Abstract

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