Nerves in cancer

Ali H. Zahalka, Paul S. Frenette

Research output: Contribution to journalReview articlepeer-review

240 Scopus citations

Abstract

The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

Original languageEnglish
Pages (from-to)143-157
Number of pages15
JournalNature Reviews Cancer
Volume20
Issue number3
DOIs
StatePublished - 1 Mar 2020

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