Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex

Margaret Fahnestock, Samuel A. Scott, Nathalie Jetté, Jean A. Weingartner, Keith A. Crutcher

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Nerve growth factor (NGF) mRNA and protein levels were determined in parietal cortex samples from both normal and Alzheimer's disease (AD) patients. NGF protein levels were slightly elevated in AD patients compared to controls, but NGF mRNA levels were unchanged in the same tissue samples. Thus, small but reproducible increases in NGF protein reported in AD cortex do not result from increases in NGF mRNA.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalMolecular Brain Research
Volume42
Issue number1
DOIs
StatePublished - Nov 1996
Externally publishedYes

Keywords

  • Basal forebrain
  • Dot blots
  • ELISA
  • Nerve growth factor
  • Neurodegeneration
  • Neurotrophic factor
  • Retrograde transport

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