TY - JOUR
T1 - Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
AU - Tybulewicz, Victor L.J.
AU - Crawford, Camila E.
AU - Jackson, Peter K.
AU - Bronson, Roderick T.
AU - Mulligan, Richard C.
PY - 1991/6/28
Y1 - 1991/6/28
N2 - The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia.
AB - The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia.
UR - http://www.scopus.com/inward/record.url?scp=0025780879&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(91)90011-M
DO - 10.1016/0092-8674(91)90011-M
M3 - Article
C2 - 2065352
AN - SCOPUS:0025780879
SN - 0092-8674
VL - 65
SP - 1153
EP - 1163
JO - Cell
JF - Cell
IS - 7
ER -