Neonatal hepatitis and excessive hepatic iron deposition following intrauterine blood transfusion

M. R. Lasker, K. Eddleman, A. H. Toor

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20 Scopus citations

Abstract

The management of hemolytic disease has undergone a number of significant changes over the past few decades. Intrauterine transfusion therapy, particularly intra-vascular transfusions, have significantly reduced the morbidity and mortality associated with isoimmunization. This therapy results not only in the transfusion of blood, but also in the transfusion of iron. The long-term consequences of iron loading in the fetus are unknown. We report a case of a newborn with Rh hemolytic disease who was treated with in utero transfusions and subsequently developed liver disease consistent with iron overload.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalAmerican Journal of Perinatology
Volume12
Issue number1
DOIs
StatePublished - 1995

Keywords

  • Rhesus isoimmunization
  • ferritin
  • intrauterine transfusion
  • iron overload
  • neonatal hepatitis

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