TY - JOUR
T1 - Nature of 3, 6-Bis(5-chloro-2-piperidinyl)-2, 5-piperazinedione-Induced Cytotoxicity in Chinese Hamster Ovary Cells
AU - Mahagaokar, Suneeta
AU - Rao, Potu N.
AU - Barlogie, Barthel
PY - 1976/12
Y1 - 1976/12
N2 - We studied the effect of 3, 6-bis(5-chloro-2-piperidinyl)-2, 5-piperazinedione (BCP) on various parameters of the replication cycle and cell growth on monolayer cultures of Chinese hamster ovary cells. The results indicated that BCP had no effect on the G1-S transition or the passage of cells from metaphase to G1. However, BCP prolonged S-and G2-phases because of its retarding effect on DNA synthesis. BCP was more toxic to Sphase cells than to G1 or mitotic cells. As with other alkylating agents, chromosome damage due to BCP could be seen only in cells that had undergone DNA replication after exposure to the drug.
AB - We studied the effect of 3, 6-bis(5-chloro-2-piperidinyl)-2, 5-piperazinedione (BCP) on various parameters of the replication cycle and cell growth on monolayer cultures of Chinese hamster ovary cells. The results indicated that BCP had no effect on the G1-S transition or the passage of cells from metaphase to G1. However, BCP prolonged S-and G2-phases because of its retarding effect on DNA synthesis. BCP was more toxic to Sphase cells than to G1 or mitotic cells. As with other alkylating agents, chromosome damage due to BCP could be seen only in cells that had undergone DNA replication after exposure to the drug.
UR - http://www.scopus.com/inward/record.url?scp=0017042031&partnerID=8YFLogxK
U2 - 10.1093/jnci/57.6.1305
DO - 10.1093/jnci/57.6.1305
M3 - Article
C2 - 1003560
AN - SCOPUS:0017042031
SN - 0027-8874
VL - 57
SP - 1305
EP - 1310
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 6
ER -