Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses

Jens C. Krause, Terrence M. Tumpey, Chelsey J. Huffman, Patricia A. McGraw, Melissa B. Pearce, Tshidi Tsibane, Rong Hai, Christopher F. Basler, James E. Crowe

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

Original languageEnglish
Pages (from-to)3127-3130
Number of pages4
JournalJournal of Virology
Volume84
Issue number6
DOIs
StatePublished - Mar 2010

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