Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses

Gary J. Kelloff; Robert L. Peters; Robert M. Donahoe; John R. Stephenson; Stuart A. Aaronson

doi:10.1093/jnci/57.1.85

Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses

Gary J. Kelloff, Robert L. Peters, Robert M. Donahoe, John R. Stephenson, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Natural tumor incidence and type C virus expression in NIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of Iymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.

Original language	English
Pages (from-to)	85-89
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	57
Issue number	1
DOIs	https://doi.org/10.1093/jnci/57.1.85
State	Published - Jul 1976
Externally published	Yes

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title = "Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses",

abstract = "Natural tumor incidence and type C virus expression in NIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of Iymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.",

author = "Kelloff, {Gary J.} and Peters, {Robert L.} and Donahoe, {Robert M.} and Stephenson, {John R.} and Aaronson, {Stuart A.}",

note = "Funding Information: 1 Received August 26, 1975; accepted January 16, 1976. 2 Conducted under Public Health Service contracts NOI CP33248 and NCI-3-73-3212 within the Virus-Cancer Program of the National Cancer Institute. 3 Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 4 Microbiological Associates, Walkersville, Md. 21793.",

year = "1976",

month = jul,

doi = "10.1093/jnci/57.1.85",

language = "English",

volume = "57",

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T1 - Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses

AU - Kelloff, Gary J.

AU - Peters, Robert L.

AU - Donahoe, Robert M.

AU - Stephenson, John R.

AU - Aaronson, Stuart A.

N1 - Funding Information: 1 Received August 26, 1975; accepted January 16, 1976. 2 Conducted under Public Health Service contracts NOI CP33248 and NCI-3-73-3212 within the Virus-Cancer Program of the National Cancer Institute. 3 Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 4 Microbiological Associates, Walkersville, Md. 21793.

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N2 - Natural tumor incidence and type C virus expression in NIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of Iymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.

AB - Natural tumor incidence and type C virus expression in NIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of Iymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.

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Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses

Abstract

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