Natural compounds: Evidence for a protective role in eye disease

Robert Ritch

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Glaucoma often progresses despite lowering of intraocular pressure (IOP) to acceptable or normal levels; it can also develop at normal or even low IOP on the basis of non-IOP-dependent risk factors. Therefore, a need exists for therapies limiting damage due to glaucoma that are independent of therapies that simply lower IOP. The aim of neuroprotection in glaucoma is to slow progression by blocking the mechanisms that lead to apoptosis. Many compounds have been described as neuroprotective, but the lack of availability of specific neuroprotectant compounds and the lack of clinical trials examining the benefits of neuroprotective agents for glaucoma limit their current therapeutic use. There are, however, many available natural compounds that offer the possibility of neuroprotective activity. This review summarizes the potential benefits of natural compounds in the treatment of eye disease.

Original languageEnglish
Pages (from-to)425-438
Number of pages14
JournalCanadian Journal of Ophthalmology
Issue number3
StatePublished - Jun 2007
Externally publishedYes


  • Alternative medicine
  • Apoptosis
  • Complementary medicine
  • Ethnopharmacology
  • Glaucoma
  • Neuroprotection


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