National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology

Lon S. Schneider, Pierre N. Tariot, Constantine G. Lyketsos, Karen S. Dagerman, Kenneth L. Davis, Sonia Davis, John K. Hsiao, Dilip V. Jeste, Ira R. Katz, Jason T. Olin, Bruce G. Pollock, Peter V. Rabins, Robert A. Rosenheck, Gary W. Small, Barry Lebowitz, Jeffery A. Lieberman

Research output: Contribution to journalArticlepeer-review

180 Scopus citations

Abstract

The authors describe the development of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) protocol for Alzheimer disease (AD), a trial developed in collaboration with the National Institute of Mental Health (NIMH), assessing the effectiveness of atypical antipsychotics for psychosis and agitation occurring in AD outpatients. They provide an overview of the methodology utilized in the trial as well as the clinical-outcomes and effectiveness measures that were implemented.

Original languageEnglish
Pages (from-to)346-360
Number of pages15
JournalAmerican Journal of Geriatric Psychiatry
Volume9
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

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