Napravlennaia modifikatsiia struktury substratov tsitokhroma P-450 kak sposob polucheniia novykh induktorov mikrosomnoǐ monooksigenaznoǐ sistemy.

Translated title of the contribution: Directed modification of the structure of cytochrome P-450 substrates as a method of generating new inducers of the microsomal monooxygenase system

I. B. Tsyrlov, K. E. Gerasimov, N. I. Gutkina, V. V. Liakhovich

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Using the previously obtained data on the substrate-type induction of monooxygenase by xenobiotics of phenobarbital type, the method of conversion of typical substrates for cytochrome P-450 into inducers of biosynthesis of this enzymatic system by blocking in the substrate molecule of the position subjected to oxidative conversion in the enzyme active center was tested. The introduction of the methyl group in the omega-1 position of amobarbital, of Cl- into positions 2 and 4 of biphenyl and the substitution of methyl groups for the isopropyl groups in the 4-N(CH3)2 position of aminopyrine provides for marked induction of these derivatives of cytochrome P-450 and some monooxygenase activities.

Translated title of the contributionDirected modification of the structure of cytochrome P-450 substrates as a method of generating new inducers of the microsomal monooxygenase system
Original languageRussian
Pages (from-to)1307-1314
Number of pages8
JournalBiokhimiya
Volume52
Issue number8
StatePublished - Aug 1987

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