Nanomedicines for endothelial disorders

Bomy Lee Chung; Michael J. Toth; Nazila Kamaly; Yoshitaka J. Sei; Jacob Becraft; Willem J.M. Mulder; Zahi A. Fayad; Omid C. Farokhzad; Yong Tae Kim; Robert Langer

doi:10.1016/j.nantod.2015.11.009

Nanomedicines for endothelial disorders

Bomy Lee Chung
, Michael J. Toth
, Nazila Kamaly
, Yoshitaka J. Sei
, Jacob Becraft
, Willem J.M. Mulder
, Zahi A. Fayad
, Omid C. Farokhzad
, Yong Tae Kim
, Robert Langer

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Summary The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

Original language	English
Pages (from-to)	759-776
Number of pages	18
Journal	Nano Today
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.nantod.2015.11.009
State	Published - Dec 2015

Keywords

Atherosclerosis
Cancer
Diabetes
Endothelial disorder
Endothelium
Nanomedicine

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10.1016/j.nantod.2015.11.009

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title = "Nanomedicines for endothelial disorders",

abstract = "Summary The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.",

keywords = "Atherosclerosis, Cancer, Diabetes, Endothelial disorder, Endothelium, Nanomedicine",

author = "\{Lee Chung\}, Bomy and Toth, \{Michael J.\} and Nazila Kamaly and Sei, \{Yoshitaka J.\} and Jacob Becraft and Mulder, \{Willem J.M.\} and Fayad, \{Zahi A.\} and Farokhzad, \{Omid C.\} and Kim, \{Yong Tae\} and Robert Langer",

year = "2015",

month = dec,

doi = "10.1016/j.nantod.2015.11.009",

language = "English",

volume = "10",

pages = "759--776",

journal = "Nano Today",

issn = "1748-0132",

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number = "6",

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TY - JOUR

T1 - Nanomedicines for endothelial disorders

AU - Lee Chung, Bomy

AU - Toth, Michael J.

AU - Kamaly, Nazila

AU - Sei, Yoshitaka J.

AU - Becraft, Jacob

AU - Mulder, Willem J.M.

AU - Fayad, Zahi A.

AU - Farokhzad, Omid C.

AU - Kim, Yong Tae

AU - Langer, Robert

PY - 2015/12

Y1 - 2015/12

N2 - Summary The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

AB - Summary The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

KW - Atherosclerosis

KW - Cancer

KW - Diabetes

KW - Endothelial disorder

KW - Endothelium

KW - Nanomedicine

UR - https://www.scopus.com/pages/publications/84959857074

U2 - 10.1016/j.nantod.2015.11.009

DO - 10.1016/j.nantod.2015.11.009

M3 - Review article

AN - SCOPUS:84959857074

SN - 1748-0132

VL - 10

SP - 759

EP - 776

JO - Nano Today

JF - Nano Today

IS - 6

ER -

Nanomedicines for endothelial disorders

Abstract

Keywords

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