Nanomaterials multifunctional behavior for enlightened cancer therapeutics

Ganji Seeta Rama Raju, Begum Dariya, Sathish Kumar Mungamuri, Gayathri Chalikonda, Sung Min Kang, Ishaq N. Khan, Pinninti Santosh Sushma, Ganji Purnachandra Nagaraju, Eluri Pavitra, Young Kyu Han

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Cancer is an outrageous disease with uncontrolled differentiation, growth, and migration to the other parts of the body. It is the second-most common cause of death both in the U.S. and worldwide. Current conventional therapies, though much improved and with better prognosis, have several limitations. Chemotherapeutic agents, for instance, are cytotoxic to both tumor and healthy cells, and the non-specific distribution of drugs at tumor sites limits the dose administered. Nanotechnology, which evolved from the coalescence and union of varied scientific disciplines, is a novel science that has been the focus of much research. This technology is generating more effective cancer therapies to overcome biomedical and biophysical barriers against standard interventions in the body; its unique magnetic, electrical, and structural properties make it a promising tool. This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.

Original languageEnglish
Pages (from-to)178-189
Number of pages12
JournalSeminars in Cancer Biology
Volume69
DOIs
StatePublished - Feb 2021
Externally publishedYes

Keywords

  • Cancer therapy
  • Drug delivery
  • Nanoparticles
  • Quantum dots

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