TY - JOUR
T1 - Nadolol in hypertensive patients maintained on long-term hemodialysis
AU - Michaels, R. S.
AU - Duchin, K. L.
AU - Akbar, S.
AU - Meister, J.
AU - Levin, N. W.
PY - 1984/10
Y1 - 1984/10
N2 - The pharmacokinetics, efficacy, and safety of nadolol were evaluated in hypertensive patients maintained on long-term hemodialysis. In nine patients the plasma elimination half-life of unchanged nadolol averaged 26 hours following a single 40 mg oral dose during the interdialytic period. Nineteen patients received nadolol once after each dialysis session. In addition, 12 of the 19 patients also received hydralazine and/or furosemide daily. Predialysis blood pressures and heart rates were significantly lower with nadolol than with combination or single therapy with conventional antihypertensive drugs, including other beta blockers. Nadolol administered only after each dialysis session (i.e., two or three times a week), in conjunction with hydralazine and/or furosemide, is an effective antihypertensive agent in hypertensive patients receiving long-term hemodialysis.
AB - The pharmacokinetics, efficacy, and safety of nadolol were evaluated in hypertensive patients maintained on long-term hemodialysis. In nine patients the plasma elimination half-life of unchanged nadolol averaged 26 hours following a single 40 mg oral dose during the interdialytic period. Nineteen patients received nadolol once after each dialysis session. In addition, 12 of the 19 patients also received hydralazine and/or furosemide daily. Predialysis blood pressures and heart rates were significantly lower with nadolol than with combination or single therapy with conventional antihypertensive drugs, including other beta blockers. Nadolol administered only after each dialysis session (i.e., two or three times a week), in conjunction with hydralazine and/or furosemide, is an effective antihypertensive agent in hypertensive patients receiving long-term hemodialysis.
UR - http://www.scopus.com/inward/record.url?scp=0021232188&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(84)90587-8
DO - 10.1016/0002-8703(84)90587-8
M3 - Article
C2 - 6148869
AN - SCOPUS:0021232188
SN - 0002-8703
VL - 108
SP - 1091
EP - 1094
JO - American Heart Journal
JF - American Heart Journal
IS - 4 PART 2
ER -