Nadolol in hypertensive patients maintained on long-term hemodialysis

R. S. Michaels, K. L. Duchin, S. Akbar, J. Meister, N. W. Levin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The pharmacokinetics, efficacy, and safety of nadolol were evaluated in hypertensive patients maintained on long-term hemodialysis. In nine patients the plasma elimination half-life of unchanged nadolol averaged 26 hours following a single 40 mg oral dose during the interdialytic period. Nineteen patients received nadolol once after each dialysis session. In addition, 12 of the 19 patients also received hydralazine and/or furosemide daily. Predialysis blood pressures and heart rates were significantly lower with nadolol than with combination or single therapy with conventional antihypertensive drugs, including other beta blockers. Nadolol administered only after each dialysis session (i.e., two or three times a week), in conjunction with hydralazine and/or furosemide, is an effective antihypertensive agent in hypertensive patients receiving long-term hemodialysis.

Original languageEnglish
Pages (from-to)1091-1094
Number of pages4
JournalAmerican Heart Journal
Volume108
Issue number4 PART 2
DOIs
StatePublished - Oct 1984
Externally publishedYes

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