N70 and P100 can be independently affected in multiple sclerosis

M. Felice Ghilardi; Ferdinando Sartucci; Julie R. Brannan; Marco C. Onofrj; Ivan Bodis-Wollner; Leland Mylin; R. Stroch

doi:10.1016/0168-5597(91)90035-V

N70 and P100 can be independently affected in multiple sclerosis

M. Felice Ghilardi, Ferdinando Sartucci, Julie R. Brannan, Marco C. Onofrj, Ivan Bodis-Wollner, Leland Mylin, R. Stroch

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

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Abstract

We have studied the relationship between N70 and P100 of the pattern visual evoked potential in 98 patients with multiple sclerosis and in 59 controls. In patients with multiple sclerosis, P100 was either absent or had prolonged latency in 121 eyes (61.7%), while N70 was absent or prolonged in 97 eyes (49.5%). The total number of eyes with either N70 and/or P100 abnormalities was 137 (69.9%). Eighty eyes (40.8%) had abnormal latency of both P100 and N70, while 41 eyes showed P100 delays without corresponding N70 changes. Seventeen eyes had abnormal N70, but normal P100 latency. N70 and P100 appear to be more often absent in the definite rather than in the possible multiple sclerosis group. These data show that N70 and P100 can be independently affected in patients with MS.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Electroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/0168-5597(91)90035-V
State	Published - 1991

Keywords

Multiple sclerosis
N70
P100
Parallel pathways
Visual evoked potential

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10.1016/0168-5597(91)90035-V

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title = "N70 and P100 can be independently affected in multiple sclerosis",

abstract = "We have studied the relationship between N70 and P100 of the pattern visual evoked potential in 98 patients with multiple sclerosis and in 59 controls. In patients with multiple sclerosis, P100 was either absent or had prolonged latency in 121 eyes (61.7%), while N70 was absent or prolonged in 97 eyes (49.5%). The total number of eyes with either N70 and/or P100 abnormalities was 137 (69.9%). Eighty eyes (40.8%) had abnormal latency of both P100 and N70, while 41 eyes showed P100 delays without corresponding N70 changes. Seventeen eyes had abnormal N70, but normal P100 latency. N70 and P100 appear to be more often absent in the definite rather than in the possible multiple sclerosis group. These data show that N70 and P100 can be independently affected in patients with MS.",

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author = "{Felice Ghilardi}, M. and Ferdinando Sartucci and Brannan, {Julie R.} and Onofrj, {Marco C.} and Ivan Bodis-Wollner and Leland Mylin and R. Stroch",

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T1 - N70 and P100 can be independently affected in multiple sclerosis

AU - Felice Ghilardi, M.

AU - Sartucci, Ferdinando

AU - Brannan, Julie R.

AU - Onofrj, Marco C.

AU - Bodis-Wollner, Ivan

AU - Mylin, Leland

AU - Stroch, R.

PY - 1991

Y1 - 1991

N2 - We have studied the relationship between N70 and P100 of the pattern visual evoked potential in 98 patients with multiple sclerosis and in 59 controls. In patients with multiple sclerosis, P100 was either absent or had prolonged latency in 121 eyes (61.7%), while N70 was absent or prolonged in 97 eyes (49.5%). The total number of eyes with either N70 and/or P100 abnormalities was 137 (69.9%). Eighty eyes (40.8%) had abnormal latency of both P100 and N70, while 41 eyes showed P100 delays without corresponding N70 changes. Seventeen eyes had abnormal N70, but normal P100 latency. N70 and P100 appear to be more often absent in the definite rather than in the possible multiple sclerosis group. These data show that N70 and P100 can be independently affected in patients with MS.

AB - We have studied the relationship between N70 and P100 of the pattern visual evoked potential in 98 patients with multiple sclerosis and in 59 controls. In patients with multiple sclerosis, P100 was either absent or had prolonged latency in 121 eyes (61.7%), while N70 was absent or prolonged in 97 eyes (49.5%). The total number of eyes with either N70 and/or P100 abnormalities was 137 (69.9%). Eighty eyes (40.8%) had abnormal latency of both P100 and N70, while 41 eyes showed P100 delays without corresponding N70 changes. Seventeen eyes had abnormal N70, but normal P100 latency. N70 and P100 appear to be more often absent in the definite rather than in the possible multiple sclerosis group. These data show that N70 and P100 can be independently affected in patients with MS.

KW - Multiple sclerosis

KW - N70

KW - P100

KW - Parallel pathways

KW - Visual evoked potential

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N70 and P100 can be independently affected in multiple sclerosis

Abstract

Keywords

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