N-cadherin mediates interaction between precursor cells in the subventricular zone and regulates further differentiation

Yoshiki Yagita, Takeshi Sakurai, Hidekazu Tanaka, Kazuo Kitagawa, David R. Colman, Weisong Shan

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Neurogenesis and cell differentiation in the brain continues throughout life. In the subventricular zone and rostral migratory stream, precursor cells contact each other. Cell-cell interactions mediated via adhesion molecules are no doubt involved in establishing and maintaining the neurogenic ability of these cells. Here, we demonstrate that N-cadherin plays important roles in forming cell clusters and in regulating cell differentiation. N-cadherin is abundantly expressed in chain migrating cells in the subventricular zone and rostral migratory stream but is down-regulated after cells exit these regions. We also show that neurosphere formation is inhibited via suppression of N-cadherin function and that N-cadherin expression is decreased after induction of neurosphere differentiation. Furthermore, we demonstrate that functional blockade of N-cadherin can enhance glial cell differentiation in explant cultures of precursors from the subventricular zone.

Original languageEnglish
Pages (from-to)3331-3342
Number of pages12
JournalJournal of Neuroscience Research
Volume87
Issue number15
DOIs
StatePublished - 15 Nov 2009

Keywords

  • Differentiation
  • N-cadherin
  • Neurogenesis
  • Neurosphere
  • Precursor

Fingerprint

Dive into the research topics of 'N-cadherin mediates interaction between precursor cells in the subventricular zone and regulates further differentiation'. Together they form a unique fingerprint.

Cite this