@article{a1337e01f7fb4b83acf241521842025d,
title = "Myopathic Cardiac Genotypes Increase Risk for Myocarditis",
abstract = "Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects (P = 0.003). Thirteen genes classically associated with cardiomyopathy or neuromuscular disorders with cardiac involvement were implicated, including >1 associated damaging variant in DYSF, DSP, and TTN. Phenotypes of subjects who have acute myocarditis with or without deleterious variants were similar, indicating that genetic testing is necessary to differentiate them.",
keywords = "acute myocarditis, cardiomyopathy, genetics",
author = "Kontorovich, {Amy R.} and Nihir Patel and Arden Moscati and Felix Richter and Inga Peter and Enkhsaikhan Purevjav and Selejan, {Simina Ramona} and Ingrid Kindermann and Towbin, {Jeffrey A.} and Michael Bohm and Karin Klingel and Gelb, {Bruce D.}",
note = "Funding Information: This study is supported in part by the National Heart Lung and Blood Institute of the National Institutes of Health (HL140083 [to Dr Kontorovich]) and (HL135742 [to Dr Gelb]), a grant from the Children{\textquoteright}s Cardiomyopathy Foundation (to Dr Kontorovich), and the German Research Foundation (KL593 2-3 [to Dr Klingel]). Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health (S10OD026880). Funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Funding Information: The authors acknowledge the Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai for use of BioMe resources. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = jul,
doi = "10.1016/j.jacbts.2021.06.001",
language = "English",
volume = "6",
pages = "584--592",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "7",
}