Myonecrosis and myofibrosis as complications of sickle cell anemia

Joanne Valeriano-Marcet, Leslie Dubin Kerr

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Painful crises in sickle cell anemia are associated with infarction and subsequent fibrosis of many different organs. Myonecrosis secondary to muscle infarction during a crisis and subsequent fibrosis are often not recognized as complications of sickle cell anemia. We describe four patients, all of whom had recurrent episodes of symmetric proximal muscle pain and swelling as prominent features of their crises. Muscle biopsies showed acute myonecrosis with a minimal inflammatory reaction as well as myofibrosis with abundant collagen deposition. Chronic sequelae consisted of muscle induration, atrophy, and contractures.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalAnnals of Internal Medicine
Issue number2
StatePublished - 15 Jul 1991


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