Myofibroblastic differentiation of stromal cells in giant cell tumor of bone: An immunohistochemical and ultrastructural study

Roberto A. Garcia, Corneliu D. Platica, M. Alba Greco, German C. Steiner

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2 Scopus citations

Abstract

The nature of the mononuclear stromal cells (MSCs) in giant cell tumor of bone (GCTB) has not been thoroughly investigated. The purpose of this study was to evaluate the degree and significance of myofibroblastic differentiation in 18 cases of GCTB by immunohistochemistry (IH) and/or electron microscopy (EM). All immunostained cases were found positive for smooth muscle actin (SMA) and/or muscle specific actin (MSA), most in 1-33% of the MSCs. Ultrastructurally, most MSCs were fibroblasts, and a significant number of cells displayed myofibroblastic differentiation. Myofibroblasts are an important component of MSCs in GCTB. The myofibroblastic population may be responsible in part for the production of matrix metalloproteinases (MMPs), which probably play a role in bone destruction, tumor aggression, and recurrence.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalUltrastructural Pathology
Volume37
Issue number3
DOIs
StatePublished - May 2013

Keywords

  • Electron microscopy
  • Giant cell tumor of bone
  • Immunohistochemistry
  • Mononuclear stromal cells
  • Myofibroblasts

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