Myoclonus: Classification, Clinical Features, and Genetics

Amar Patel; Steven Frucht

doi:10.1016/B978-0-12-405195-9.00040-8

Myoclonus: Classification, Clinical Features, and Genetics

Amar Patel, Steven Frucht

Icahn School of Medicine at Mount Sinai

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Myoclonus is a hyperkinetic movement disorder present in a wide variety of neurologic disorders. Myoclonus may be generated at all levels of the nervous system from cortical, subcortical, segmental, and peripheral centers. Classification of myoclonus by its physiology can help the clinician localize the site of pathology and help refine diagnosis. Some physiological myoclonus types are characteristically seen in particular disorders and respond to particular therapies. Electroencephalography and electromyography aid in characterizing myoclonus physiology and etiology. Etiologic classification of myoclonus distinguishes four broad categories: physiologic, essential, epileptic, and secondary (or symptomatic) myoclonus. The genetic heterogeneity of disorders underlying myoclonus is extensive and continues to be elucidated.

Original language	English
Title of host publication	Movement Disorders
Subtitle of host publication	Genetics and Models: Second Edition
Publisher	Elsevier Inc.
Pages	655-670
Number of pages	16
ISBN (Print)	9780124051959
DOIs	https://doi.org/10.1016/B978-0-12-405195-9.00040-8
State	Published - 29 Oct 2014

Keywords

Epileptic myoclonus
Essential myoclonus
Myoclonus
Myoclonus classification
Physiologic myoclonus
Secondary myoclonus

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10.1016/B978-0-12-405195-9.00040-8

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abstract = "Myoclonus is a hyperkinetic movement disorder present in a wide variety of neurologic disorders. Myoclonus may be generated at all levels of the nervous system from cortical, subcortical, segmental, and peripheral centers. Classification of myoclonus by its physiology can help the clinician localize the site of pathology and help refine diagnosis. Some physiological myoclonus types are characteristically seen in particular disorders and respond to particular therapies. Electroencephalography and electromyography aid in characterizing myoclonus physiology and etiology. Etiologic classification of myoclonus distinguishes four broad categories: physiologic, essential, epileptic, and secondary (or symptomatic) myoclonus. The genetic heterogeneity of disorders underlying myoclonus is extensive and continues to be elucidated.",

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Myoclonus: Classification, Clinical Features, and Genetics

Abstract

Keywords

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