Myocarditis as a complication in scleroderma patients with myositis

Leslie Dubin Kerr, Harry Spiera

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


This report describes six diffuse scleroderma (PSS) patients with skeletal muscle myositis accompanied by severe myocarditis, diagnosed by CPK‐MB elevation in conjunction with severe left ventricular (LV) hypokinesis. Although the myositis improved with steroid therapy in all patients, those treated with steroids alone died due to progressive LV failure. This experience suggests that the LV dysfunction in PSS patients with myositis may have an inflammatory component. Since the myocarditis may not be clinically apparent initially, it is suggested that CPK‐MB fractionation and studies of LV function are undertaken in all PSS patients with myositis. The optimal treatment of this disorder, however, has yet to be determined.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalClinical Cardiology
Issue number12
StatePublished - Dec 1993


  • myocarditis
  • myositis
  • scleroderma


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