TY - JOUR
T1 - Myocardial regenerative properties of macrophage populations and stem cells
AU - Santini, Maria Paola
AU - Rosenthal, Nadia
N1 - Funding Information:
Acknowledgements We thank all members of the Rosenthal Laboratory at Imperial College London for reading the manuscript. MPS and NR are supported by the British Heart Foundation Project grants number PG/10/019 and PG/08/111. NR is an NHMRC Australia Fellow.
PY - 2012/10
Y1 - 2012/10
N2 - The capacity to regenerate damaged tissue and appendages is lost to some extent in higher vertebrates such as mammals, which form a scar tissue at the expenses of tissue reconstitution and functionality. Whereas this process can protect from further damage and elicit fast healing, it can lead to functional deterioration in organs such as the heart. Based on the analyses performed in the last years, stem cell therapies may not be sufficient to induce cardiac regeneration and additional approaches are required to overcome scar formation. Among these, the immune cells and their humoral response have become a key parameter in regenerative processes. In this review, we will describe the recent findings on the possible therapeutical use of progenitor and immune cells to rescue a damaged heart.
AB - The capacity to regenerate damaged tissue and appendages is lost to some extent in higher vertebrates such as mammals, which form a scar tissue at the expenses of tissue reconstitution and functionality. Whereas this process can protect from further damage and elicit fast healing, it can lead to functional deterioration in organs such as the heart. Based on the analyses performed in the last years, stem cell therapies may not be sufficient to induce cardiac regeneration and additional approaches are required to overcome scar formation. Among these, the immune cells and their humoral response have become a key parameter in regenerative processes. In this review, we will describe the recent findings on the possible therapeutical use of progenitor and immune cells to rescue a damaged heart.
KW - Cardiac progenitor cells
KW - Cardiac regeneration
KW - Fibrosis
KW - Inflammation
KW - Macrophage populations
UR - http://www.scopus.com/inward/record.url?scp=84874149674&partnerID=8YFLogxK
U2 - 10.1007/s12265-012-9383-6
DO - 10.1007/s12265-012-9383-6
M3 - Article
C2 - 22684511
AN - SCOPUS:84874149674
SN - 1937-5387
VL - 5
SP - 700
EP - 712
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 5
ER -