Myocardial imaging with 9-[Te-123m]telluraheptadecanoic acid

D. R. Elmaleh; F. F. Knapp; T. Yasuda; J. L. Coffey; S. Kopiwoda; R. Okada; H. W. Strauss

Myocardial imaging with 9-[Te-123m]telluraheptadecanoic acid

D. R. Elmaleh
, F. F. Knapp
, T. Yasuda
, J. L. Coffey
, S. Kopiwoda
, R. Okada
, H. W. Strauss

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery has been determined after intravenous injection of 9-[Te-123m]telluraheptadecanoic acid (Te-123m HDA). In rats the normal myocardium concentrated radioactivity (3.7% ± 0.28 injected dose/g) to nearly three times that in the zones of infarction (1.12% ± 0.18 dose/g). The focal defects detected in the gamma-camera images of rats and dogs corresponds well with areas of infarction identified in the excised hearts by staining with triphenyl-tetrazolium chloride. The distribution of radioactivity from Te-123m HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with scandium-46-labeled microspheres.

Original language	English
Pages (from-to)	994-999
Number of pages	6
Journal	Journal of Nuclear Medicine
Volume	22
Issue number	11
State	Published - 1981

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title = "Myocardial imaging with 9-[Te-123m]telluraheptadecanoic acid",

abstract = "The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery has been determined after intravenous injection of 9-[Te-123m]telluraheptadecanoic acid (Te-123m HDA). In rats the normal myocardium concentrated radioactivity (3.7\% ± 0.28 injected dose/g) to nearly three times that in the zones of infarction (1.12\% ± 0.18 dose/g). The focal defects detected in the gamma-camera images of rats and dogs corresponds well with areas of infarction identified in the excised hearts by staining with triphenyl-tetrazolium chloride. The distribution of radioactivity from Te-123m HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with scandium-46-labeled microspheres.",

author = "Elmaleh, \{D. R.\} and Knapp, \{F. F.\} and T. Yasuda and Coffey, \{J. L.\} and S. Kopiwoda and R. Okada and Strauss, \{H. W.\}",

year = "1981",

language = "English",

volume = "22",

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journal = "Journal of Nuclear Medicine",

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publisher = "Society of Nuclear Medicine Inc.",

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TY - JOUR

T1 - Myocardial imaging with 9-[Te-123m]telluraheptadecanoic acid

AU - Elmaleh, D. R.

AU - Knapp, F. F.

AU - Yasuda, T.

AU - Coffey, J. L.

AU - Kopiwoda, S.

AU - Okada, R.

AU - Strauss, H. W.

PY - 1981

Y1 - 1981

N2 - The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery has been determined after intravenous injection of 9-[Te-123m]telluraheptadecanoic acid (Te-123m HDA). In rats the normal myocardium concentrated radioactivity (3.7% ± 0.28 injected dose/g) to nearly three times that in the zones of infarction (1.12% ± 0.18 dose/g). The focal defects detected in the gamma-camera images of rats and dogs corresponds well with areas of infarction identified in the excised hearts by staining with triphenyl-tetrazolium chloride. The distribution of radioactivity from Te-123m HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with scandium-46-labeled microspheres.

AB - The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery has been determined after intravenous injection of 9-[Te-123m]telluraheptadecanoic acid (Te-123m HDA). In rats the normal myocardium concentrated radioactivity (3.7% ± 0.28 injected dose/g) to nearly three times that in the zones of infarction (1.12% ± 0.18 dose/g). The focal defects detected in the gamma-camera images of rats and dogs corresponds well with areas of infarction identified in the excised hearts by staining with triphenyl-tetrazolium chloride. The distribution of radioactivity from Te-123m HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with scandium-46-labeled microspheres.

UR - https://www.scopus.com/pages/publications/0019851519

M3 - Article

C2 - 7299486

AN - SCOPUS:0019851519

SN - 0161-5505

VL - 22

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EP - 999

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 11

ER -

Myocardial imaging with 9-[Te-123m]telluraheptadecanoic acid

Abstract

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