Myeloproliferative neoplasms

Sangeetha Venugopal, Daniel Aruch, John Mascarenhas

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Myeloproliferative neoplasms (MPNs) are a heterogeneous group of hematologic diseases in the World Health Organization Classification characterized by clonal myeloid proliferation. The last decade has provided an immense amount of knowledge that has improved our ability to diagnose, risk stratify, and treat these blood cancers. In particular, the development of tyrosine kinase inhibitors has dramatically improved the survival in chronic myelogenous leukemia while the discovery of JAK2, MPL, CSF3R, CKIT, and CALR mutations has refined our ability to diagnose and categorize other myeloproliferative neoplasms with hope for future targeted therapies.

Original languageEnglish
Title of host publicationOncology
Number of pages17
ISBN (Electronic)9781119189596
ISBN (Print)9781119189558
StatePublished - 30 Aug 2019


  • Chronic myelogenous leukemia
  • Erythrocytosis
  • Essential thrombocythemia
  • Leukocytosis
  • Mastocytosis
  • Myeloproliferative neoplasms
  • Neutrophilia
  • Polycythemia vera
  • Thrombocytosis


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