Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.

Original languageEnglish
Pages (from-to)1061-1066
Number of pages6
JournalHuman Immunology
Issue number11
StatePublished - Nov 2010


  • Myeloid derived suppressor cells
  • Organ transplantation
  • Tolerance


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