Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin rainier and treated with 32P

Vesna Najfeld; Thomas H. Price; John W. Adamson; Philip J. Fialkow

doi:10.1002/ajh.2830050109

Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin rainier and treated with ³²P

Vesna Najfeld
, Thomas H. Price
, John W. Adamson
, Philip J. Fialkow

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with ³²P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51, XX, +1, 2q‐(q33), +6, +9, +11, ‐19, +20q +,+ mar 1). This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.

Original language	English
Pages (from-to)	63-69
Number of pages	7
Journal	American Journal of Hematology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830050109
State	Published - 1978
Externally published	Yes

Keywords

Hemoglobin Rainier
P
chromosome 1, 6, 9, and 11 aberrations
cytogenetics
hematology
hemoglobinopathy
myelofibrosis
myeloproliferative disorder

Access to Document

10.1002/ajh.2830050109

Cite this

@article{f66bb829f1be46f6a7ecf1c3f27f85db,

title = "Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin rainier and treated with 32P",

abstract = "A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51, XX, +1, 2q‐(q33), +6, +9, +11, ‐19, +20q +,+ mar 1). This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.",

keywords = "Hemoglobin Rainier, P, chromosome 1, 6, 9, and 11 aberrations, cytogenetics, hematology, hemoglobinopathy, myelofibrosis, myeloproliferative disorder",

author = "Vesna Najfeld and Price, \{Thomas H.\} and Adamson, \{John W.\} and Fialkow, \{Philip J.\}",

year = "1978",

doi = "10.1002/ajh.2830050109",

language = "English",

volume = "5",

pages = "63--69",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin rainier and treated with 32P

AU - Najfeld, Vesna

AU - Price, Thomas H.

AU - Adamson, John W.

AU - Fialkow, Philip J.

PY - 1978

Y1 - 1978

N2 - A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51, XX, +1, 2q‐(q33), +6, +9, +11, ‐19, +20q +,+ mar 1). This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.

AB - A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51, XX, +1, 2q‐(q33), +6, +9, +11, ‐19, +20q +,+ mar 1). This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.

KW - Hemoglobin Rainier

KW - P

KW - chromosome 1, 6, 9, and 11 aberrations

KW - cytogenetics

KW - hematology

KW - hemoglobinopathy

KW - myelofibrosis

KW - myeloproliferative disorder

UR - https://www.scopus.com/pages/publications/0018237409

U2 - 10.1002/ajh.2830050109

DO - 10.1002/ajh.2830050109

M3 - Article

C2 - 747183

AN - SCOPUS:0018237409

SN - 0361-8609

VL - 5

SP - 63

EP - 69

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 1